In order to discover genetic variations, interaction between genes and environment and the underlying pathways of brain disorders, high quality exposure data from longitudinal studies are required. This data provides information of direct clinical, aetiological and public health relevance, as well as data on observable phenotypes.


  • processing of samples (DNA isolation, quantification, preparation for competitive initiatives; RNA isolation);
  • proof of principle studies (expression, proteomics and epigenetics studies);
  • support in sample management and sample tracking;
  • support for linking phenotype and genotype databases.


A centralized biobank infrastructure has been implemented for the collection, storage and provision of samples for scientific usage. This biobank will contain all the facilities and quality protocols with legal and ethical oversight, archiving, laboratories, security, data management and inventory systems.

Sample collections

  • NTR (Netherlands Twin Register)
  • NESDA (depression and anxiety)
  • NESDO (depression among the elderly)
  • LASA (elderly population based sample psychiatry, health and social behavior)
  • ALS Postmortem Brain & Biobank Collection
  • Meningitis Obduction Collection
  • Alzheimer Centre VUmc
  • MS Center Amsterdam
  • Netherlands Brain Bank.