Mutant mouse lines are a vital part for unravelling the signalling pathways of neurological and neuropsychiatric diseases. The Center for Neurogenomics and Cognitive Research (CNCR) – being an integral partner of Amsterdam Neuroscience – has a large number (>100) of in-house developed mutant mouse models. They can be combined with specific, scientific expertise in neurosciences and cell biological research, to unravel disease related signalling pathways. Thereby, a translational link is provided between pre-clinical animal studies, discovery of novel biomarkers and novel treatments for patient care.
By combining pre-clinical mouse models of neurological and neuropsychiatric diseases with mouse pharmaphenomics, the effective use of prescribed drugs, the identification of novel lead compounds and novel treatment tools for brain disorders, can be investigated and (re-)designed into new intervention strategies.
Efficient, high-throughput behaviour assays in mice can be offered, benefiting from an automated monitoring system, using on-line video tracking 24/7, as well as traditional in depth phenotyping in numerous validated behavioural assays. This work is executed in collaboration with a national consortium and is executed, using an in-house MouseHouse facility (see also NeuroBasic PharmaPhenomics)